PAPPA 抗体 (AA 351-523)
Our Local Distributor
北京 101111
Quick Overview for PAPPA 抗体 (AA 351-523) (ABIN7874241)
抗原
See all PAPPA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 351-523
-
原理
- PAPP-A Antibody / Pappalysin-1
-
纯化方法
- Protein G affinity chromatography
-
免疫原
- A portion of amino acids 351-523 from the human protein was used as the immunogen for the PAPP-A antibody.
-
亚型
- IgG2b, kappa
-
-
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 351-523) antibody
PAPPA 适用: 人 IHC 宿主: 小鼠 Monoclonal PAPPA-2715 unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 1321-1460) antibodyPAPPA 适用: 人, 小鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 351-523) antibodyPAPPA 适用: 人 IHC 宿主: 小鼠 Monoclonal 780M unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 999-1272) antibodyPAPPA 适用: 小鼠 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 317-532) antibodyPAPPA 适用: 人 IHC, WB, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 95-302) antibodyPAPPA 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 1270-1558) antibodyPAPPA 适用: 人 IHC, WB, IP, ICC 宿主: 小鼠 Monoclonal H4 unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 85-194) antibodyPAPPA 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G3 unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 95-388) antibodyPAPPA 适用: 人 IHC, WB 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 1270-1558) antibodyPAPPA 适用: 人 IHC, WB, FACS 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Optimal dilution of the PAPP-A antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min. -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Store the PAPP-A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
-
-
- PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))
-
别名
- PAPP-A
-
背景
- Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).
-
UniProt
- Q13219
抗原
-
