MCM4 抗体 (AA 343-659)
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Quick Overview for MCM4 抗体 (AA 343-659) (ABIN7874108)
抗原
See all MCM4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 343-659
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原理
- Zebrafish Mcm4 Antibody
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纯化方法
- Antigen affinity chromatography
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免疫原
- An E.coli-derived zebrafish Mcm4 recombinant protein (amino acids M343-I659) was used as the immunogen for the Zebrafish Mcm4 antibody.
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亚型
- Ig Fraction
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anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 1-863) antibody
MCM4 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 1-863) antibodyMCM4 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) antibodyMCM4 适用: 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 2-141) antibodyMCM4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 750-800) antibodyMCM4 适用: 人, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 325-375) antibodyMCM4 适用: 人 IHC 宿主: 山羊 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 325-375) antibodyMCM4 适用: 人, 小鼠 WB, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) (AA 750-800) antibodyMCM4 适用: 人, 小鼠 WB, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Minichromosome Maintenance Deficient 4 (MCM4) antibodyMCM4 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4960 unconjugated Recombinant Antibody
anti-Minichromosome Maintenance Deficient 4 (MCM4) antibodyMCM4 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB2495 unconjugated Recombinant Antibody
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应用备注
- Optimal dilution of the Zebrafish Mcm4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Mcm4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MCM4 (Minichromosome Maintenance Deficient 4 (MCM4))
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别名
- Mcm4
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背景
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Minichromosome maintenance complex component 4 (MCM4) is a core part of the MCM2-7 helicase complex, which is essential for the initiation and elongation phases of eukaryotic DNA replication. The MCM complex functions as the replicative helicase, unwinding double-stranded DNA at replication forks to enable the synthesis of new DNA strands.
In zebrafish (Danio rerio), mcm4 is a highly conserved gene with critical roles during early embryogenesis and cell proliferation. Expression of mcm4 is enriched in rapidly dividing tissues and during periods of intense developmental activity, reflecting its importance in genome stability and cell cycle progression.
Zebrafish models deficient in Mcm4 function have been used to study mechanisms of DNA replication stress, genomic instability, and the cellular response to DNA damage. Additionally, because of its conservation and similarity to human MCM4, zebrafish serves as a useful system for modeling MCM-related human disorders, such as Meier-Gorlin syndrome and cancer predisposition syndromes linked to replication licensing defects.
The zebrafish MCM4 protein is a valuable tool for investigating DNA replication dynamics, cell cycle regulation, and the molecular basis of developmental and proliferative diseases.
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UniProt
- Q6NZV2
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途径
- DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA
抗原
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