MAG 抗体 (AA 34-605)
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北京 101111
Quick Overview for MAG 抗体 (AA 34-605) (ABIN7874086)
抗原
See all MAG 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 34-605
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原理
- Siglec-4a Antibody / MAG / Myelin-associated glycoprotein
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纯化方法
- Affinity purified
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免疫原
- A human recombinant partial protein (amino acids E34-R605) was used as the immunogen for the Siglec-4a antibody.
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亚型
- IgG2a
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anti-Myelin Associated Glycoprotein (MAG) (AA 439-466) antibody
MAG 适用: 人, 小鼠, 大鼠 WB, FACS 宿主: 兔 Polyclonal RB21439 unconjugated
anti-Myelin Associated Glycoprotein (MAG) (AA 133-237) antibodyMAG 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myelin Associated Glycoprotein (MAG) (AA 119-208) antibodyMAG 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3C7 unconjugated
anti-Myelin Associated Glycoprotein (MAG) (AA 25-516) antibodyMAG 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myelin Associated Glycoprotein (MAG) antibodyMAG 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Myelin Associated Glycoprotein (MAG) antibodyKD Validated MAG 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB2600 unconjugated Recombinant Antibody
anti-Myelin Associated Glycoprotein (MAG) (AA 114-132), (N-Term) antibodyMAG 适用: 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myelin Associated Glycoprotein (MAG) (AA 34-605) antibodyMAG 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, IF 宿主: 小鼠 Monoclonal 2G11 unconjugated
anti-Myelin Associated Glycoprotein (MAG) (AA 501-582) antibodyMAG 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Myelin Associated Glycoprotein (MAG) (AA 551-626) antibodyMAG 适用: 人, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Siglec-4a antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Siglec-4a antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MAG (Myelin Associated Glycoprotein (MAG))
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别名
- Siglec-4a
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背景
- MAG (Myelin-associated glycoprotein), also known as Siglec-4a, is a cell membrane glycoprotein that is a member of the SIGLEC family of proteins and is a functional ligand of the NOGO-66 receptor, NgR. It is though to be involved in the process of myelination. MAG is a sialic acid-binding SIGLEC protein and is a functional ligand for the NOGO receptor.The MAG gene is mapped on 19q13.12. Cleavage of GPI-linked proteins from axons protects growth cones from MAG-induced collapse, and dominant-negative NgR eliminates MAG inhibition of neurite outgrowth. MAG-resistant embryonic neurons were rendered MAG-sensitive by expression of NgR. MAG binds specifically to an NgR-expressing cell line in a GPI-dependent and sialic acid-independent manner. Experiments blocking NgR from interacting with MAG prevented inhibition of neurite outgrowth by MAG. In cultured human embryonic kidney(HEK) cells expressing the NOGO receptor, p75(NTR) was required for MAG-induced intracellular calcium elevation.
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UniProt
- P20916
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途径
- Neurotrophin Signaling Pathway
抗原
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