RNLS 抗体 (AA 34-235)
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Quick Overview for RNLS 抗体 (AA 34-235) (ABIN7874066)
抗原
See all RNLS 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 34-235
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原理
- Renalase Antibody (azide and preservative free)
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纯化方法
- Protein G affinity
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免疫原
- A portion of amino acids 34-235 from the human protein was used as the immunogen for the Renalase antibody.
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亚型
- IgG2b, kappa
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应用备注
- Optimal dilution of the Renalase antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the Renalase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- RNLS (Renalase, FAD-Dependent Amine Oxidase (RNLS))
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别名
- Renalase
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背景
- Renalase is a 342 amino acid FAD-dependent amine oxidase that is highly expressed in kidney and is expressed at a lower level in heart, skeletal muscle and small intestine. Renalase is secreted in the blood by the kidney and it is thought to regulate cardiac function and systemic blood pressure. It is also suggested that Renalase functions as a hormone that metabolizes circulating catecholamines, which have an active role in the sympathetic and parasympathetic nervous systems. Individuals with chronic kidney disease and end-stage renal disease have markedly reduced levels of plasma Renalase than healthy individuals. Infusion of Renalase in animal models causes decrease in heart rate, cardiac contractility and blood pressure. Two isoforms of Renalase exist due to alternative splicing events.
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UniProt
- Q5VYX0
抗原
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