CPT2 抗体 (AA 33-646)
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Quick Overview for CPT2 抗体 (AA 33-646) (ABIN7874010)
抗原
See all CPT2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 33-646
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原理
- CPT2 Antibody / Carnitine O-palmitoyltransferase 2
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纯化方法
- Antigen Affinity purified
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免疫原
- Amino acids Q33-D646 from the human protein were used as the immunogen for the CPT2 antibody.
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亚型
- IgG
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anti-Carnitine Palmitoyltransferase 2 (CPT2) (Internal Region) antibody
CPT2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Carnitine Palmitoyltransferase 2 (CPT2) (AA 1-180) antibodyCPT2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Carnitine Palmitoyltransferase 2 (CPT2) (AA 141-154) antibodyVerified CPT2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Carnitine Palmitoyltransferase 2 (CPT2) (AA 1-658) antibodyCPT2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Carnitine Palmitoyltransferase 2 (CPT2) (AA 212-241) antibodyCPT2 适用: 人 WB 宿主: 兔 Polyclonal RB41839 unconjugated
anti-Carnitine Palmitoyltransferase 2 (CPT2) (AA 351-450) antibodyCPT2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G7 unconjugated
anti-Carnitine Palmitoyltransferase 2 (CPT2) (AA 1-658) antibodyCPT2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Carnitine Palmitoyltransferase 2 (CPT2) (AA 351-450) antibodyCPT2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Carnitine Palmitoyltransferase 2 (CPT2) (AA 388-551) antibodyCPT2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Carnitine Palmitoyltransferase 2 (CPT2) (AA 431-462), (C-Term) antibodyCPT2 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal RB04659-04660 unconjugated
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应用备注
- Optimal dilution of the CPT2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the CPT2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- CPT2 (Carnitine Palmitoyltransferase 2 (CPT2))
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别名
- CPT2
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背景
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CPT2 antibody is a widely used reagent for studying fatty acid metabolism, mitochondrial function, and energy homeostasis. The encoded protein, carnitine O-palmitoyltransferase 2 (CPT2), is a key enzyme in the carnitine shuttle system that transports long-chain fatty acids into mitochondria for beta-oxidation. Located on the inner mitochondrial membrane, CPT2 catalyzes the conversion of acylcarnitine back to acyl-CoA, enabling fatty acids to undergo oxidation and generate ATP. This function makes CPT2 essential for energy production, particularly during fasting, exercise, and other metabolic stresses.
CPT2 operates in close coordination with CPT1, which resides on the outer mitochondrial membrane, and carnitine-acylcarnitine translocase (CACT), which shuttles acylcarnitines across the inner membrane. Together, these enzymes form a highly regulated system ensuring the efficient use of fatty acids as fuel. By facilitating long-chain fatty acid oxidation, CPT2 contributes to metabolic flexibility, energy balance, and cellular survival under nutrient-limited conditions.
Genetic defects in the CPT2 gene are the cause of carnitine palmitoyltransferase II deficiency, a rare inherited metabolic disorder. Clinical presentations include lethal neonatal forms, severe infantile hepatocardiomuscular disease, and the most common myopathic form characterized by recurrent episodes of muscle weakness, rhabdomyolysis, and myoglobinuria. These conditions highlight the indispensable role of CPT2 in energy metabolism and underscore its clinical significance. Mutations affecting CPT2 disrupt fatty acid oxidation, leading to impaired ATP production and accumulation of toxic lipid intermediates.
In addition to its metabolic importance, CPT2 has been implicated in broader biological processes, including thermogenesis and regulation of lipid signaling pathways. Research has also linked altered CPT2 activity to metabolic syndromes, insulin resistance, and susceptibility to muscle-related disorders. Its central role in lipid utilization makes CPT2 a critical subject of investigation in both basic and translational research.
The CPT2 antibody is widely applied in western blotting, immunohistochemistry, immunofluorescence, and flow cytometry to measure protein expression, localization, and regulation. These applications are useful for assessing mitochondrial metabolism, characterizing genetic deficiencies, and exploring therapeutic approaches for metabolic disease. For researchers focused on lipid metabolism, muscle biology, or mitochondrial disorders, the CPT2 antibody provides a reliable detection tool. NSJ Bioreagents offers validated antibodies that ensure reproducibility and accuracy in advanced molecular studies. -
UniProt
- P23786
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途径
- Regulation of Lipid Metabolism by PPARalpha, Monocarboxylic Acid Catabolic Process
抗原
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