IL7R 抗体 (AA 33-433)
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北京 101111
Quick Overview for IL7R 抗体 (AA 33-433) (ABIN7874001)
抗原
See all IL7R 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 33-433
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原理
- CD127 Antibody
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纯化方法
- Antigen affinity chromatography
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免疫原
- An E.coli-derived human recombinant protein (amino acids A33-Q433) was used as the immunogen for the CD127 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the CD127 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the CD127 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- IL7R (Interleukin 7 Receptor (IL7R))
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别名
- CD127
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背景
- The interleukin-7 receptor, also known as IL7R alpha, is a protein found on the surface of cells. It is mapped to 5p13. Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V(D)J recombination. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID).
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UniProt
- P16871
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途径
- JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size
抗原
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