DKK2 抗体 (AA 31-62)
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Quick Overview for DKK2 抗体 (AA 31-62) (ABIN7873799)
抗原
See all DKK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 31-62
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原理
- Dickkopf-2 Antibody / DKK2
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纯化方法
- Purified
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免疫原
- A portion of amino acids 31-62 from the human protein was used as the immunogen for the Dickkopf-2 antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the Dickkopf-2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Dickkopf-2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- DKK2 (Dickkopf 2 Homolog (DKK2))
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别名
- Dickkopf-2
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背景
- The 259-amino acid DKK2 protein, like DKK1, DKK3, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cys residues each. The second cys region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed expression of 4.0- and 4.5-kb DKK2 transcripts in heart, brain, skeletal muscle, and lung. Western blot analysis showed that DKK2 is secreted as a 15- to 17-kD protein. Functional analysis determined that DKK2 does not block Xenopus Wnt8 induction of a secondary axis in frog embryos.
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UniProt
- Q9UBU2
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途径
- WNT signaling
抗原
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