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DKK2 抗体 (AA 31-62)

This 兔 多克隆 antibody specifically detects DKK2 in WB 和 IHC (p). It exhibits reactivity toward 人 和 小鼠.
产品编号 ABIN7873799
发货至: 中国
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Quick Overview for DKK2 抗体 (AA 31-62) (ABIN7873799)

抗原

See all DKK2 抗体
DKK2 (Dickkopf 2 Homolog (DKK2))

适用

  • 55
  • 19
  • 5
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
人, 小鼠

宿主

  • 47
  • 7
  • 1

克隆类型

  • 48
  • 7
多克隆

标记

  • 31
  • 7
  • 4
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This DKK2 antibody is un-conjugated

应用范围

  • 41
  • 24
  • 22
  • 7
  • 2
  • 2
  • 2
  • 2
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • 抗原表位

    • 8
    • 8
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 31-62

    原理

    Dickkopf-2 Antibody / DKK2

    纯化方法

    Purified

    免疫原

    A portion of amino acids 31-62 from the human protein was used as the immunogen for the Dickkopf-2 antibody.

    亚型

    Ig Fraction
  • 应用备注

    The stated application concentrations are suggested starting points. Titration of the Dickkopf-2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    In 1X PBS, pH 7.4, with 0.09 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the Dickkopf-2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    DKK2 (Dickkopf 2 Homolog (DKK2))

    别名

    Dickkopf-2

    背景

    The 259-amino acid DKK2 protein, like DKK1, DKK3, and DKK4, possesses an N-terminal signal peptide and 2 conserved cysteine-rich domains, which are separated by a linker region and contain 10 cys residues each. The second cys region has a putative lipid-binding function that may facilitate WNT/DKK interactions at the plasma membrane. The linker region contains 50 to 55 amino acids in DKK1, DKK2, and DKK4, whereas in DKK3 it contains only 12 amino acids. All DKKs have several potential sites for cleavage by furin-type proteases. Northern blot analysis revealed expression of 4.0- and 4.5-kb DKK2 transcripts in heart, brain, skeletal muscle, and lung. Western blot analysis showed that DKK2 is secreted as a 15- to 17-kD protein. Functional analysis determined that DKK2 does not block Xenopus Wnt8 induction of a secondary axis in frog embryos.

    UniProt

    Q9UBU2

    途径

    WNT signaling
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