SERBP1 抗体 (AA 3-139)
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Quick Overview for SERBP1 抗体 (AA 3-139) (ABIN7873509)
抗原
See all SERBP1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 3-139
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原理
- SERBP1 Antibody / PAI-RBP1 (azide and preservative free)
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纯化方法
- Protein G affinity chromatography
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免疫原
- A recombinant human partial protein corresponding to amino acids 3-139 was used as the immunogen for the SERBP1 antibody.
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亚型
- IgG2b, kappa
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应用备注
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Optimal dilution of the SERBP1 antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the SERBP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))
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别名
- SERBP1
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背景
- PAI-RBP1 (plasminogen activator inhibitor 1 RNA-binding protein), also known as SERBP1 (SERPINE1 mRNA-binding protein 1), CGI-55, CHD3IP (chromodomain helicase DNA binding protein 3 interacting protein), HABP4L or PAI-RBP1, is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. PAI-RBP1 is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, PAI-RBP1 interacts with Mi2-alpha and may be involved in chromatin remodeling. PAI-RBP1 also interacts with PGRMC1 and participates in the transduction of Progesterone's antiapoptotic action in ovarian cell types. The gene encoding PAI-RBP1 is overexpressed in ovarian cancer, suggesting a possible role for PAI-RBP1 in tumorigenesis and tumor metastasis.
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UniProt
- Q8NC51
抗原
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