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SERBP1 抗体 (AA 3-139)

The 小鼠 单克隆 anti-SERBP1 antibody is suitable to detect SERBP1 in samples from 人. It has been validated for WB 和 IHC (p).
产品编号 ABIN7873497
发货至: 中国
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北京 101111
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Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for SERBP1 抗体 (AA 3-139) (ABIN7873497)

抗原

See all SERBP1 抗体
SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

适用

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宿主

  • 72
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小鼠

克隆类型

  • 70
  • 37
单克隆

标记

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This SERBP1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

Carrier-free

克隆位点

SERBP1-3498
  • 抗原表位

    • 63
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    AA 3-139

    原理

    SERBP1 Antibody / PAI-RBP1 (azide and preservative free)

    纯化方法

    Protein G affinity chromatography

    免疫原

    A recombinant human partial protein corresponding to amino acids 3-139 was used as the immunogen for the SERBP1 antibody.

    亚型

    IgG1, kappa
  • 应用备注

    Optimal dilution of the SERBP1 antibody should be determined by the researcher.

    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    4 °C,-20 °C

    储存方法

    Store the SERBP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
  • 抗原

    SERBP1 (SERPINE1 mRNA Binding Protein 1 (SERBP1))

    别名

    SERBP1

    背景

    PAI-RBP1 (plasminogen activator inhibitor 1 RNA-binding protein), also known as SERBP1 (SERPINE1 mRNA-binding protein 1), CGI-55, CHD3IP (chromodomain helicase DNA binding protein 3 interacting protein), HABP4L or PAI-RBP1, is a membrane-associated protein that localizes to the nucleus, the perinuclear region of the cytoplasm and the plasma membrane. PAI-RBP1 is believed to play a role in the regulation of mRNA stability, as it specifically binds to the CRS (cyclic nucleotide-responsive sequence) motif of the PAI-1 mRNA and acts to stabilize the mRNA and regulate its expression. In addition, PAI-RBP1 interacts with Mi2-alpha and may be involved in chromatin remodeling. PAI-RBP1 also interacts with PGRMC1 and participates in the transduction of Progesterone's antiapoptotic action in ovarian cell types. The gene encoding PAI-RBP1 is overexpressed in ovarian cancer, suggesting a possible role for PAI-RBP1 in tumorigenesis and tumor metastasis.

    UniProt

    Q8NC51
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