Haptoglobin 抗体 (AA 296-322)
Our Local Distributor
北京 101111
Quick Overview for Haptoglobin 抗体 (AA 296-322) (ABIN7873465)
抗原
See all Haptoglobin (HP) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 296-322
-
原理
- Haptoglobin Antibody / HP
-
纯化方法
- Antigen affinity purified
-
免疫原
- A portion of amino acids 296-322 from the human protein was used as the immunogen for the Haptoglobin antibody.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- The stated application concentrations are suggested starting points. Titration of the Haptoglobin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the Haptoglobin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
-
-
- Haptoglobin (HP)
-
别名
- Haptoglobin
-
背景
- This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene.
-
UniProt
- P00738
-
途径
- Transition Metal Ion Homeostasis
抗原
-