MUS81 抗体 (AA 283-483)
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Quick Overview for MUS81 抗体 (AA 283-483) (ABIN7873310)
抗原
See all MUS81 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 283-483
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原理
- MUS81 Antibody
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids H283-R483) was used as the immunogen for the MUS81 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the MUS81 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MUS81 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MUS81 (MUS81 Endonuclease Homolog (MUS81))
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别名
- MUS81
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背景
- Crossover junction endonuclease MUS81 is an enzyme that in humans is encoded by the MUS81 gene. This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks.
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UniProt
- Q96NY9
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途径
- DNA Damage Repair
抗原
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