NDRG1 抗体 (AA 28-296)
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Quick Overview for NDRG1 抗体 (AA 28-296) (ABIN7873250)
抗原
See all NDRG1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 28-296
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原理
- Zebrafish Ndr1 Antibody / Nodal-related 1
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Ndr1 recombinant protein (amino acids Q28-D296) was used as the immunogen for the Zebrafish Ndr1 antibody.
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亚型
- Ig Fraction
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anti-N-Myc Downstream Regulated 1 (NDRG1) (pSer330) antibody
KD Validated NDRG1 适用: 人 WB, FACS, IF (p) 宿主: 兔 Monoclonal 24GB4985 unconjugated Recombinant Antibody
anti-N-Myc Downstream Regulated 1 (NDRG1) (AA 1-394) antibodyNDRG1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2D7 unconjugated
anti-N-Myc Downstream Regulated 1 (NDRG1) (C-Term) antibodyVerified NDRG1 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-N-Myc Downstream Regulated 1 (NDRG1) antibodyNDRG1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-N-Myc Downstream Regulated 1 (NDRG1) antibodyKD Validated NDRG1 适用: 人 WB, FACS, ICC 宿主: 兔 Monoclonal 24GB8605 unconjugated Recombinant Antibody
anti-N-Myc Downstream Regulated 1 (NDRG1) (AA 12-40), (N-Term) antibodyNDRG1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21832 unconjugated
anti-N-Myc Downstream Regulated 1 (NDRG1) (AA 12-40) antibodyNDRG1 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-N-Myc Downstream Regulated 1 (NDRG1) antibodyNDRG1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Monoclonal 4C8 unconjugated Recombinant Antibody
anti-N-Myc Downstream Regulated 1 (NDRG1) (AA 136-394) antibodyNDRG1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-N-Myc Downstream Regulated 1 (NDRG1) (AA 1-395) antibodyNDRG1 适用: 人 WB, IHC, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2D7 unconjugated
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应用备注
- Optimal dilution of the Zebrafish Ndr1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Ndr1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- NDRG1 (N-Myc Downstream Regulated 1 (NDRG1))
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别名
- Ndr1
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背景
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Nodal related 1, also known as Squint and Ndr1, is a member of the transforming growth factor beta superfamily and plays a key role in early embryonic development in zebrafish. It is involved in the establishment of the body axis, mesoderm and endoderm formation, and the specification of left right asymmetry. Nodal related 1 functions as a secreted signaling molecule that activates intracellular pathways through binding to type one and type two serine threonine kinase receptors.
Zebrafish Nodal related 1 is considered a functional homolog of human NODAL, although it is not a direct one to one ortholog due to lineage specific gene duplications in teleost fish. However, both proteins are part of the same signaling pathway and perform highly conserved roles in vertebrate embryogenesis. Like human NODAL, zebrafish Nodal related 1 signals through the SMAD family of transcription factors and is regulated by feedback mechanisms involving antagonists such as Lefty and Cerberus.
Expression of Nodal related 1 begins during the blastula stage and becomes concentrated in the embryonic margin, where it helps induce and pattern the mesendoderm. Mutations or knockdown of this gene result in severe defects in gastrulation, germ layer formation, and organ development. Due to its essential role in vertebrate development and strong functional conservation, zebrafish Nodal related 1 is widely studied in developmental biology, cell signaling, and disease modeling.
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UniProt
- O13144
抗原
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