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LAT 抗体 (AA 28-235)

Name: LAT 抗体 (AA 28-235)
SKU: ABIN7873245
Availability: OutOfStock

The 兔多克隆 anti-LAT antibody is suitable to detect LAT in samples from 人. It has been validated for WB, ELISA 和 FACS.

产品编号 ABIN7873245

发货至: 中国

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中国
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Quick Overview for LAT 抗体 (AA 28-235) (ABIN7873245)

抗原

See all LAT 抗体

LAT (Linker For Activation of T Cells (LAT))

适用

人

宿主

兔

克隆类型

多克隆

标记

This LAT antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Discover our top product LAT Primary Antibody

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AA 28-235

原理

LAT Antibody / Linker for activation of T-cells family member 1

纯化方法

Immunogen affinity purified

免疫原

E.coli-derived human LAT recombinant protein (Position: H28-E235) was used as the immunogen for the LAT antibody.

亚型

IgG
anti-Linker For Activation of T Cells (LAT) (Cytoplasmic Domain) antibody
LAT 适用: 人 WB, IP, ICFC 宿主: 小鼠 Monoclonal LAT-01 unconjugated

anti-Linker For Activation of T Cells (LAT) antibody
LAT 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Linker For Activation of T Cells (LAT) (pTyr191) antibody
LAT 适用: 人 WB, ELISA, IHC, IP, IF 宿主: 兔 Monoclonal 2E4 unconjugated Recombinant Antibody

anti-Linker For Activation of T Cells (LAT) antibody
KD Validated LAT 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB4940 unconjugated Recombinant Antibody

anti-Linker For Activation of T Cells (LAT) (AA 1-233) antibody
LAT 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3B11-1D5 unconjugated

anti-Linker For Activation of T Cells (LAT) (AA 30-237) antibody
LAT 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Linker For Activation of T Cells (LAT) (pTyr161) antibody
LAT 适用: 人 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Linker For Activation of T Cells (LAT) (Cytoplasmic Domain) antibody
LAT 适用: 人 WB, IHC, IP, IHC (p) 宿主: 小鼠 Monoclonal LAT1111 unconjugated

anti-Linker For Activation of T Cells (LAT) (AA 25-221) antibody
LAT 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Linker For Activation of T Cells (LAT) (AA 33-227) antibody
LAT 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal dilution of the LAT antibody should be determined by the researcher.

限制

仅限研究用
状态

Lyophilized

溶解方式

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

储存条件

4 °C,-20 °C

储存方法

After reconstitution, the LAT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
抗原

LAT (Linker For Activation of T Cells (LAT))

别名

LAT

背景

LAT antibody detects Linker for activation of T-cells family member 1, encoded by the LAT gene. Linker for activation of T-cells family member 1 is a transmembrane adaptor protein expressed in T cells and natural killer cells, where it serves as a central scaffold for antigen receptor signaling. LAT antibody provides researchers with a critical reagent for studying T cell receptor signaling, immune responses, and related diseases.

Linker for activation of T-cells family member 1 localizes to lipid rafts in the plasma membrane. Research using LAT antibody has shown that upon T cell receptor stimulation, LAT becomes tyrosine-phosphorylated by ZAP70. These phosphorylated residues recruit multiple signaling proteins, including GRB2, PLCG1, and GADS, forming a large signaling complex. This assembly drives calcium signaling, MAPK activation, and transcription of immune effector genes.

Studies with LAT antibody have demonstrated that LAT is indispensable for T cell development and activation. Knockout models lacking LAT fail to develop mature T cells, and mutations in LAT impair signaling pathways required for adaptive immunity. These findings emphasize its role as a master regulator of immune receptor signaling.

Dysregulation of LAT contributes to disease. Research using LAT antibody has revealed that mutations in the LAT gene cause severe combined immunodeficiency, characterized by absent or impaired T cell function. Aberrant LAT signaling has also been implicated in autoimmune disease, where inappropriate activation leads to tissue damage. In oncology, altered LAT expression influences T cell activity within the tumor microenvironment, affecting anti-tumor immunity.

LAT antibody is widely used in immunoprecipitation, immunoblotting, and flow cytometry. Immunoprecipitation identifies signaling complexes assembled at LAT, immunoblotting detects phosphorylated and total protein levels, and flow cytometry quantifies expression in T cell populations. These applications make LAT antibody indispensable in immunology research.

By supplying validated LAT antibody reagents, NSJ Bioreagents supports studies into T cell receptor signaling, immune development, and pathology. Detection of Linker for activation of T-cells family member 1 provides researchers with insight into how scaffold proteins regulate receptor signaling networks.

UniProt

O43561

途径

TCR Signaling, Fc-epsilon Receptor Signaling Pathway