Phospholipase C beta 2 抗体 (AA 27-1185)
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Quick Overview for Phospholipase C beta 2 抗体 (AA 27-1185) (ABIN7873076)
抗原
See all Phospholipase C beta 2 (PLCb2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 27-1185
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原理
- PLCB2 Antibody / Phospholipase C-beta-2
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human PLCB2 recombinant protein (Position: D27-L1185) was used as the immunogen for the PLCB2 antibody.
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亚型
- IgG
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anti-phospholipase C beta 2 (PLCb2) (AA 1-250) antibody
PLCb2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C beta 2 (PLCb2) (AA 1-250) antibodyPLCb2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C beta 2 (PLCb2) (AA 174-202), (N-Term) antibodyPLCb2 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB17392 unconjugated
anti-phospholipase C beta 2 (PLCb2) (AA 1-250) antibodyPLCb2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C beta 2 (PLCb2) (AA 1-199) antibodyPLCb2 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 1B3 unconjugated
anti-phospholipase C beta 2 (PLCb2) (Internal Region) antibodyPLCb2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C beta 2 (PLCb2) (AA 1031-1185) antibodyPLCb2 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C beta 2 (PLCb2) (AA 1-199) antibodyPLCb2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-phospholipase C beta 2 (PLCb2) (AA 401-500) antibody (AbBy Fluor® 647)PLCb2 适用: 人, 小鼠 WB, FACS, IF (cc), IF (p) 宿主: 兔 Polyclonal AbBy Fluor® 647
anti-phospholipase C beta 2 (PLCb2) antibodyPLCb2 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PLCB2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PLCB2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Phospholipase C beta 2 (PLCb2) (phospholipase C beta 2 (PLCb2))
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别名
- PLCB2
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背景
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The PLCB2 antibody targets 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (Phospholipase C-beta-2), an enzyme encoded by the PLCB2 gene. This beta isoform of phospholipase C hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). These products regulate calcium signaling and protein kinase C activation, forming a critical pathway downstream of G-protein-coupled receptors (GPCRs) and immune receptors. The PLCB2 antibody provides a specific tool for exploring phosphoinositide signaling, calcium homeostasis, and receptor-mediated cellular activation.
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 is widely expressed in hematopoietic and epithelial cells. It interacts with G alpha q and G beta gamma subunits of heterotrimeric G-proteins, linking receptor activation to intracellular calcium mobilization. The PLCB2 antibody enables detection of this enzyme in tissues where rapid signal transduction is required, such as immune cells and neurons. Its enzymatic activity is central to processes like secretion, chemotaxis, and proliferation.
PLCB2 plays a pivotal role in innate and adaptive immunity by coupling receptor engagement to downstream effector responses. The PLCB2 antibody supports investigations into Fc receptor signaling, platelet activation, and leukocyte migration. Dysregulation of phospholipase C beta-2 can lead to aberrant immune signaling, inflammation, and altered calcium dynamics that contribute to autoimmune or cardiovascular disorders.
In addition to its immune functions, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 contributes to sensory transduction in olfactory and gustatory pathways. The PLCB2 antibody is therefore valuable for neuroscience and sensory-biology research. Knockout models reveal its necessity in taste signaling and mucosal immune defense.
The PLCB2 antibody performs effectively in western blotting, immunofluorescence, and immunohistochemistry, typically revealing cytoplasmic and membrane-associated staining. NSJ Bioreagents provides this antibody as a validated, high-specificity reagent for cell signaling, immunology, and biochemistry research. By enabling accurate detection of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2, the PLCB2 antibody advances understanding of G-protein-coupled signaling networks and calcium-dependent cellular processes. -
UniProt
- Q00722
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途径
- WNT signaling, Thyroid Hormone Synthesis, CXCR4-mediated Signaling Events, G-protein mediated Events, Thromboxane A2 Receptor Signaling
抗原
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