IL4 Receptor 抗体 (AA 26-719)
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Quick Overview for IL4 Receptor 抗体 (AA 26-719) (ABIN7873015)
抗原
See all IL4 Receptor (IL4R) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 26-719
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原理
- Il4 receptor Antibody
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纯化方法
- Affinity purified
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免疫原
- A rat recombinant partial protein (amino acids I26-E719) was used as the immunogen for the Il4 receptor antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Il4 receptor antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Il4 receptor antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- IL4 Receptor (IL4R) (Interleukin 4 Receptor (IL4R))
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别名
- Il4 receptor
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背景
- IL4R (INTERLEUKIN 4 RECEPTOR) is a human gene that encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. The IL4R gene is localized to 16p12.1-p11.2 by in situ hybridization and Southern blot analysis of DNA from a panel of mouse-human somatic cell lines. IL4 plays a major role in immunoglobulin E(IgE) production. Its signal is conferred to effector cells through binding to the alpha chain of the IL4 receptor. IL4 interacts with IL4R with high affinity, leading to dimerization with either the common gamma chain,a component of receptors for a number of cytokines, to create a type I receptor, or with IL13RA1 to form a type II receptor.The IL4R gene contains 12 exons and IL4R is a complex of at least 2 components, one of which is a novel affinity converting subunit that is critical for cellular signal transduction. See also IL13RA1 and IL13RA2.
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UniProt
- Q63257
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途径
- JAK/STAT Signaling, Positive Regulation of Immune Effector Process
抗原
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