N-Cadherin 抗体 (AA 25-810)
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Quick Overview for N-Cadherin 抗体 (AA 25-810) (ABIN7872893)
抗原
See all N-Cadherin (CDH2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 25-810
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原理
- Zebrafish N-cadherin Antibody / Ncad / Cdh2 / Cadherin 2
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish N-cadherin recombinant protein (amino acids M25-R810) was used as the immunogen for the Zebrafish N-cadherin antibody.
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亚型
- Ig Fraction
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anti-Cadherin 2 (CDH2) (AA 701-800) antibody
CDH2 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 2 (CDH2) antibodyCDH2 适用: 人, 小鼠, 犬, 猴 WB, IHC, FACS, IHC (p) 宿主: 小鼠 Monoclonal 2G7 unconjugated
anti-Cadherin 2 (CDH2) (AA 750-850) antibodyCDH2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 2 (CDH2) antibodyCDH2 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 5D5 unconjugated
anti-Cadherin 2 (CDH2) (AA 45-238) antibodyCDH2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 2 (CDH2) (AA 160-724) antibodyCDH2 适用: 人, 小鼠 WB, IP, FACS, ICC 宿主: 兔 Monoclonal BLR097G unconjugated Recombinant Antibody
anti-Cadherin 2 (CDH2) (AA 690-770) antibodyCDH2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 2 (CDH2) (AA 295-414) antibodyCDH2 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 2 (CDH2) (AA 685-784) antibodyCDH2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cadherin 2 (CDH2) (Extracellular Domain) antibodyCDH2 适用: 人, 小鼠 WB, IHC, IF, FACS 宿主: 小鼠 Monoclonal 8C11 unconjugated
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应用备注
- Optimal dilution of the Zebrafish N-cadherin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish N-cadherin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- N-Cadherin (CDH2) (Cadherin 2 (CDH2))
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别名
- N-cadherin
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背景
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N cadherin, also known as Ncad, cadherin 2 and neural cadherin, is a calcium dependent cell adhesion molecule that plays a critical role in the formation and maintenance of tissue architecture during development. In zebrafish, N cadherin is essential for processes such as gastrulation, neurulation, somite formation, and organ morphogenesis.
Zebrafish N cadherin is the ortholog of the human CDH2 gene, which encodes the same protein. Both zebrafish and human N cadherin are members of the classical cadherin family and share a conserved structure that includes extracellular cadherin repeats, a single transmembrane domain, and a cytoplasmic region that interacts with catenins to link cell adhesion to the actin cytoskeleton.
In zebrafish embryos, N cadherin is expressed in the developing nervous system, heart, somites, and other tissues undergoing epithelial to mesenchymal transitions. It mediates homophilic cell-cell adhesion, ensuring coordinated cell movements and stable tissue organization. Loss of N cadherin function in zebrafish results in severe developmental defects, including impaired brain morphogenesis, defective heart formation, and abnormal cell migration.
Due to its strong evolutionary conservation and fundamental role in cell adhesion and signaling, zebrafish N cadherin is widely used as a model to study developmental biology, tissue engineering, cancer metastasis, and congenital disorders involving cadherin dysfunction.
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UniProt
- Q90275
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途径
- Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane
抗原
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