Rubicon 抗体 (AA 241-271)
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北京 101111
Quick Overview for Rubicon 抗体 (AA 241-271) (ABIN7872730)
抗原
See all Rubicon (KIAA0226) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 241-271
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原理
- Rubicon Antibody / RUBCN / BARON
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 241-271 from the human protein was used as the immunogen for the Rubicon antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the Rubicon antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Rubicon antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Rubicon (KIAA0226) (KIAA0226)
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别名
- Rubicon
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背景
- Inhibits PIK3C3 activity, under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process. Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation. [UniProt]
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UniProt
- Q92622
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途径
- Autophagy
抗原
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