TEK 抗体 (AA 23-616)
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Quick Overview for TEK 抗体 (AA 23-616) (ABIN7872548)
抗原
See all TEK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 23-616
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原理
- TIE2 Antibody
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纯化方法
- Affinity purified
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免疫原
- A human recombinant protein (amino acids A23-R616) was used as the immunogen for the TIE2 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the TIE2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TIE2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TEK (TEK Tyrosine Kinase, Endothelial (TEK))
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别名
- TIE2
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背景
- TIE2, also known as TEK tyrosine kinase, is mapped to 9p21.2. This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Immunoblotting showed that TIE2 expression was increased by thyroid-stimulating hormone and agents that increased intracellular cAMP. HSCs expressing the receptor tyrosine kinase TIE2 are quiescent and antiapoptotic and comprise a side population of HSCs that adhere to osteoblasts in the bone marrow niche.
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UniProt
- Q02763
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途径
- RTK signaling, Growth Factor Binding
抗原
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