FIP1L1 抗体 (AA 23-558)
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北京 101111
Quick Overview for FIP1L1 抗体 (AA 23-558) (ABIN7872545)
抗原
See all FIP1L1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 23-558
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原理
- FIP1L1 Antibody / Pre-mRNA 3'-end-processing factor FIP1
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids E23-E558) was used as the immunogen for the FIP1L1 antibody.
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亚型
- IgG
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anti-FIP1 Like 1 (FIP1L1) antibody
FIP1L1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-FIP1 Like 1 (FIP1L1) (AA 1-300) antibodyFIP1L1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-FIP1 Like 1 (FIP1L1) (AA 1-378) antibodyFIP1L1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2H4 unconjugated
anti-FIP1 Like 1 (FIP1L1) antibodyFIP1L1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-FIP1 Like 1 (FIP1L1) antibodyFIP1L1 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-FIP1 Like 1 (FIP1L1) (AA 509-558) antibodyFIP1L1 适用: 人, 小鼠, 大鼠, Cow, 马, 犬, Pig, 豚鼠, 斑马鱼, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-FIP1 Like 1 (FIP1L1) (AA 23-558) antibodyFIP1L1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ELISA, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-FIP1 Like 1 (FIP1L1) (C-Term) antibodyFIP1L1 适用: 人, 小鼠, 大鼠, Cow, 马, 犬, 豚鼠, 斑马鱼, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the FIP1L1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the FIP1L1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- FIP1L1 (FIP1 Like 1 (FIP1L1))
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别名
- FIP1L1
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背景
- Factor interacting with PAPOLA and CPSF1 (i.e, FIP1L1, also termed Pre-mRNA 3'-end-processing factor FIP1) is a protein that in humans is encoded by the FIP1L1 gene (also known as Rhe, FIP1, and hFip1). This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
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UniProt
- Q6UN15
抗原
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