RAD51D 抗体 (AA 23-328)
Our Local Distributor
北京 101111
Quick Overview for RAD51D 抗体 (AA 23-328) (ABIN7872526)
抗原
See all RAD51D 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 23-328
-
原理
- RAD51D Antibody / RAD51 homolog D
-
纯化方法
- Immunogen affinity purified
-
免疫原
- E.coli-derived human RAD51D recombinant protein (Position: H23-T328) was used as the immunogen for the RAD51D antibody.
-
亚型
- IgG
-
-
anti-RAD51 Homolog D (RAD51D) (AA 1-216) antibody
RAD51D 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-RAD51 Homolog D (RAD51D) (AA 1-328) antibodyRAD51D 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1C8-3C12 unconjugated
anti-RAD51 Homolog D (RAD51D) (C-Term) antibodyRAD51D 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-RAD51 Homolog D (RAD51D) (AA 1-328) antibodyRAD51D 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-RAD51 Homolog D (RAD51D) antibodyRAD51D 适用: 人 WB, FACS 宿主: 兔 Monoclonal 24GB5175 unconjugated Recombinant Antibody
anti-RAD51 Homolog D (RAD51D) (AA 1-100) antibodyRAD51D 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-RAD51 Homolog D (RAD51D) (AA 1-216) antibodyRAD51D 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-RAD51 Homolog D (RAD51D) (C-Term) antibodyRAD51D 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-RAD51 Homolog D (RAD51D) antibodyRAD51D 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-RAD51 Homolog D (RAD51D) (AA 259-308) antibodyRAD51D 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
- Optimal dilution of the RAD51D antibody should be determined by the researcher.
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
-
缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- After reconstitution, the RAD51D antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
-
-
- RAD51D (RAD51 Homolog D (RAD51D))
-
别名
- RAD51D
-
背景
-
RAD51D antibody detects DNA repair protein RAD51 homolog D, encoded by the RAD51D gene. RAD51D is a member of the RAD51 family of proteins that mediate homologous recombination, a high-fidelity DNA repair pathway essential for genome stability. RAD51D antibody provides researchers with a tool for studying DNA repair, recombination, and cancer susceptibility.
RAD51D functions by promoting strand invasion and pairing between homologous DNA sequences during double-strand break repair. Research using RAD51D antibody has shown that it forms complexes with other RAD51 paralogs, including RAD51B, RAD51C, and XRCC2, to stabilize DNA intermediates and ensure proper recombination. These interactions highlight RAD51D as a core mediator of genome maintenance.
Studies with RAD51D antibody have revealed that mutations in RAD51D predispose individuals to hereditary ovarian and breast cancer. Loss-of-function mutations compromise homologous recombination, leading to accumulation of DNA breaks and genomic instability. This genetic predisposition places RAD51D in the same pathway as BRCA1 and BRCA2, emphasizing its importance in hereditary cancer risk.
In addition to hereditary cancer, RAD51D has relevance in therapeutic contexts. Research using RAD51D antibody has demonstrated that cells deficient in RAD51D are highly sensitive to PARP inhibitors, which exploit synthetic lethality in DNA repair-deficient cancers. This makes RAD51D an important biomarker for precision oncology strategies.
RAD51D antibody is widely applied in western blotting, immunofluorescence, and chromatin immunoprecipitation. Western blotting quantifies expression in cell lines and tumor tissues, immunofluorescence highlights nuclear foci formation in response to DNA damage, and chromatin immunoprecipitation identifies DNA repair complexes. These methods make RAD51D antibody indispensable for DNA repair research.
By providing validated RAD51D antibody reagents, NSJ Bioreagents supports studies into DNA repair, hereditary cancer, and precision medicine. Detection of DNA repair protein RAD51 homolog D provides researchers with insight into how recombination pathways maintain genomic integrity. -
UniProt
- O75771
抗原
-
