MCM6 抗体 (AA 228-368)
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Quick Overview for MCM6 抗体 (AA 228-368) (ABIN7872423)
抗原
See all MCM6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 228-368
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原理
- MCM6 Antibody
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纯化方法
- Protein G affinity chromatography
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免疫原
- A recombinant human partial protein (amino acids 228-368) was used as the immunogen for this MCM6 antibody.
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亚型
- IgG2b, kappa
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应用备注
- Optimal dilution of the MCM6 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the MCM6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- MCM6 (Minichromosome Maintenance Complex Component 6 (MCM6))
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别名
- MCM6
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背景
- The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM6 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1/S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the post-replicative state of the cell. MCM2/MCM6 complexes function as substrates for Cdc2/cyclin B in vitro.
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UniProt
- Q14566
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途径
- DNA Damage Repair, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
抗原
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