MID1 抗体 (AA 226-278)
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Quick Overview for MID1 抗体 (AA 226-278) (ABIN7872405)
抗原
See all MID1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 226-278
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原理
- MID1 Antibody
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纯化方法
- Affinity purified
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免疫原
- Amino acids N226-Q278 from the human protein were used as the immunogen for the MID1 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the MID1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- Store the MID1 antibody at -20oC.
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- MID1 (Midline 1 (MID1))
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别名
- MID1
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背景
- Midline-1 is a protein found in humans that is encoded by the MID1 gene. The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also known as the 'RING-B box-coiled coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein forms homodimers which associate with microtubules in the cytoplasm. The protein is likely involved in the formation of multiprotein structures acting as anchor points to microtubules. Mutations in this gene have been associated with the X-linked form of Opitz syndrome, which is characterized by midline abnormalities such as cleft lip, laryngeal cleft, heart defects, hypospadias, and agenesis of the corpus callosum. This gene was also the first example of a gene subject to X inactivation in human while escaping it in mouse. Alternative promoter use, alternative splicing and alternative polyadenylation result in multiple transcript variants that have different tissue specificities.
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UniProt
- O15344
抗原
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