OAT 抗体 (AA 223-444)
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Quick Overview for OAT 抗体 (AA 223-444) (ABIN7872379)
抗原
See all OAT 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 223-444
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原理
- Zebrafish Ornithine aminotransferase Antibody / Oat
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纯化方法
- Antigen affinity chromatography
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免疫原
- E. coli-derived zebrafish Ornithine aminotransferase recombinant protein (amino acids A223-F444) was used as the immunogen for the Zebrafish Ornithine aminotransferase antibody.
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亚型
- Ig Fraction
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anti-Ornithine Aminotransferase (OAT) (AA 1-301) antibody
OAT 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Ornithine Aminotransferase (OAT) (AA 160-439) antibodyOAT 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Ornithine Aminotransferase (OAT) (AA 27-55), (N-Term) antibodyOAT 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB21924 unconjugated
anti-Ornithine Aminotransferase (OAT) (AA 214-439) antibodyOAT 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Ornithine Aminotransferase (OAT) (Middle Region) antibodyOAT 适用: 人, 小鼠, 大鼠, Cow, 马, 兔, 斑马鱼, 犬, 豚鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Ornithine Aminotransferase (OAT) antibodyOAT 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ornithine Aminotransferase (OAT) antibodyOAT 适用: 人 IHC, IHC (p) 宿主: 小鼠 Monoclonal AT23A2 unconjugated
anti-Ornithine Aminotransferase (OAT) (C-Term) antibodyOAT 适用: 人, 小鼠, 大鼠, Cow, 马, 兔, 斑马鱼, 犬, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ornithine Aminotransferase (OAT) (AA 33-439) antibodyOAT 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal AT23A2 unconjugated
anti-Ornithine Aminotransferase (OAT) (Internal Region) antibodyOAT 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Zebrafish Ornithine aminotransferase antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Zebrafish Ornithine aminotransferase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- OAT (Ornithine Aminotransferase (OAT))
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别名
- Ornithine aminotransferase
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背景
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Ornithine aminotransferase, also known as OAT, is a mitochondrial enzyme that plays a key role in amino acid metabolism, particularly in the urea cycle and the synthesis of proline and glutamate. It catalyzes the reversible transamination of ornithine to glutamate semialdehyde, which is an important intermediate in nitrogen and energy metabolism.
In zebrafish, ornithine aminotransferase is expressed in multiple tissues including the liver, kidney, brain, and eye, reflecting its essential role in cellular homeostasis and metabolic balance. The zebrafish ornithine aminotransferase gene is an ortholog of the human OAT gene. Both proteins share high sequence similarity and conserved functional domains, supporting the use of zebrafish as a model for studying OAT related biology and disease.
Functionally, ornithine aminotransferase is critical for regulating the intracellular balance of ornithine and proline, which are important for collagen synthesis, antioxidant responses, and retinal function. In humans, mutations in the OAT gene are associated with a rare metabolic disorder known as gyrate atrophy of the choroid and retina, which leads to progressive vision loss. Zebrafish models have been used to study the developmental and physiological consequences of OAT deficiency, especially in ocular and hepatic systems.
Due to its evolutionary conservation and key metabolic functions, zebrafish ornithine aminotransferase is a valuable target in research areas including developmental biology, metabolism, neurobiology, and genetic disease modeling.
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UniProt
- F8W5L3
抗原
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