PCDHA12 抗体 (AA 219-365)
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Quick Overview for PCDHA12 抗体 (AA 219-365) (ABIN7872260)
抗原
See all PCDHA12 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 219-365
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原理
- Protocadherin alpha 12 Antibody / PCDHA12
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纯化方法
- Antigen affinity chromatography
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免疫原
- An E.coli-derived human recombinant protein (amino acids K219-V365) was used as the immunogen for the Protocadherin alpha 12 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Protocadherin alpha 12 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Protocadherin alpha 12 Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PCDHA12 (Protocadherin alpha 12 (PCDHA12))
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别名
- Protocadherin alpha 12
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背景
- Protocadherin alpha-12 is a protein that in humans is encoded by the PCDHA12 gene. This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
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UniProt
- Q9UN75
抗原
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