MSL1 抗体 (AA 218-614)
The 兔 多克隆 anti-MSL1 antibody is suitable to detect MSL1 in samples from 人 和 大鼠. It has been validated for WB, ELISA, FACS, ICC, IF 和 IHC.
产品编号 ABIN7872258
发货至:
中国
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Quick Overview for MSL1 抗体 (AA 218-614) (ABIN7872258)
抗原
See all MSL1 抗体
MSL1
(Male-Specific Lethal 1 Homolog (MSL1))
适用
人, 大鼠
宿主
兔
克隆类型
多克隆
标记
This MSL1 antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC)
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抗原表位
- AA 218-614
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原理
- MSL1 Antibody / Male-specific lethal 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human MSL1 recombinant protein (Position: Q218-K614) was used as the immunogen for the MSL1 antibody.
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亚型
- IgG
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anti-Male-Specific Lethal 1 Homolog (MSL1) (AA 210-300) antibody
MSL1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the MSL1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the MSL1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- MSL1 (Male-Specific Lethal 1 Homolog (MSL1))
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别名
- MSL1
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背景
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MSL1 antibody detects Male-specific lethal 1 homolog, a chromatin-associated protein that forms part of the MSL (male-specific lethal) complex responsible for histone acetylation and dosage compensation. Originally discovered in Drosophila, the human MSL complex includes MSL1, MSL2, MSL3, and the histone acetyltransferase KAT8 (also known as MOF). Together, these proteins catalyze histone H4 lysine 16 acetylation, a mark associated with transcriptional activation. The MSL1 antibody is widely used in chromatin biology and epigenetic regulation studies to explore histone modification and gene dosage balance.
MSL1 is encoded by the MSL1 gene located on human chromosome Xq28. The protein is approximately 618 amino acids long and contains coiled-coil regions that mediate interactions with MSL2 and MSL3, stabilizing the MSL complex structure. MSL1 localizes primarily to euchromatic regions of the nucleus and contributes to the spreading of acetylated histone marks along active genes. The protein serves as a scaffold, ensuring the recruitment and correct assembly of other MSL subunits onto chromatin.
The MSL1 antibody detects a 75 kilodalton band by western blot and demonstrates nuclear staining in cells undergoing active transcription. Through its role in facilitating KAT8-dependent histone H4 acetylation, MSL1 influences global chromatin accessibility and transcriptional output. Loss of MSL1 disrupts histone acetylation patterns and leads to altered gene expression profiles, particularly affecting dosage-sensitive genes on the X chromosome.
Beyond its role in dosage compensation, MSL1 participates in general transcriptional regulation across autosomes. It has been linked to stem cell differentiation, stress responses, and genome organization. Abnormal expression or mutation of MSL1 alters chromatin structure and is associated with cancer and neurodevelopmental disorders. As a regulator of chromatin state, MSL1 bridges histone modification machinery with transcriptional control mechanisms that shape epigenetic identity.
Because of its central function in chromatin remodeling and transcriptional activation, MSL1 serves as a valuable marker for studies of epigenetic regulation, gene dosage balance, and histone acetylation. NSJ Bioreagents provides a validated MSL1 antibody optimized for its applications, supporting research into histone modification, dosage compensation, and nuclear organization. -
UniProt
- Q68DK7
抗原
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