MLF1 抗体 (AA 215-244)
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北京 101111
Quick Overview for MLF1 抗体 (AA 215-244) (ABIN7872230)
抗原
See all MLF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 215-244
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原理
- MLF1 Antibody / Myeloid leukemia factor 1
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 215-244 from the human protein was used as the immunogen for the MLF1 antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the MLF1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the MLF1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- MLF1 (Myeloid Leukemia Factor 1 (MLF1))
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别名
- MLF1
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背景
- MLF1 is involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. The protein interferes with erythopoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. It suppresses RFWD2/COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. It binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus.
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UniProt
- P58340
抗原
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