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Recombinant Decorin 抗体 (AA 212-336)

This 兔 单克隆 antibody specifically detects Decorin in IHC (p). It exhibits reactivity toward 人.
产品编号 ABIN7872209
发货至: 中国
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Quick Overview for Recombinant Decorin 抗体 (AA 212-336) (ABIN7872209)

抗原

See all Decorin (DCN) 抗体
Decorin (DCN)

抗体类型

Recombinant Antibody

适用

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  • 1

宿主

  • 77
  • 42
  • 4
  • 1
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克隆类型

  • 72
  • 53
单克隆

标记

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This Decorin antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

质量等级

Carrier-free

克隆位点

DCN-8760R
  • 抗原表位

    • 30
    • 9
    • 6
    • 6
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    AA 212-336

    原理

    Decorin Antibody / DCN (azide and preservative free)

    纯化方法

    Protein A/G affinity

    免疫原

    A recombinant human Decorin protein fragment (within amino acids 212-336) was used as the immunogen for the Decorin antibody.

    亚型

    IgG, kappa
  • 应用备注

    Optimal dilution of the Decorin antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 mg/mL

    缓冲液

    1 mg/mL in 1X PBS, BSA free, sodium azide free

    储存液

    Azide free

    储存条件

    -20 °C

    储存方法

    Aliquot the Decorin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    Decorin (DCN)

    别名

    Decorin

    背景

    Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGFbeta and is a direct or indirect negative modulator of TGFbeta synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN-gamma and TNFAlpha may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. For immunostaining, pre-incubation with chondroitinase-SBC or testicular hyaluronidase may be required to expose the epitope.

    UniProt

    P07585

    途径

    Glycosaminoglycan Metabolic Process
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