LAMP1 抗体 (AA 200-400)
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北京 101111
Quick Overview for LAMP1 抗体 (AA 200-400) (ABIN7872029)
抗原
See all LAMP1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 200-400
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原理
- CD107a Antibody / LAMP1
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the CD107a antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the CD107a antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the CD107a antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- LAMP1 (Lysosomal-Associated Membrane Protein 1 (LAMP1))
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别名
- CD107a
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背景
- Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. LAMP-1 (also designated CD107a) and LAMP-2 (also designated CD107b) are involved in a variety of functions, including cellular adhesion, and are thought to participate in the process of tumor invasion and metastasis. Newly synthesized LAMP-1 and LAMP-2 proteins are sorted at the trans-Golgi network and are transported intracellularly via a pathway that is distinct from the Clathrincoated vesicles used for the mannose-6 phosphate receptor. LAMP-1 is expressed on the surface of Thrombin-activated but not resting platelets, and it is thought to be involved in the adhesive, prothrombic properties of these cells. Both LAMP-1 and LAMP-2 are involved in maintaining lysosome acidity and protecting the lysosomal membranes from autodigestion, and their expression is increased in patients with lysosomal storage disorders.
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UniProt
- P11279
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途径
- Autophagy
抗原
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