Recombinant Decorin 抗体 (AA 200-359)
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Quick Overview for Recombinant Decorin 抗体 (AA 200-359) (ABIN7871980)
抗原
See all Decorin (DCN) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
克隆位点
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抗原表位
- AA 200-359
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原理
- Recombinant DCN Antibody / Decorin (azide and preservative free)
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant human Decorin protein fragment (within amino acids 200-359) was used as the immunogen for the recombinant DCN antibody.
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亚型
- IgG2b, kappa
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应用备注
- Optimal dilution of the recombinant DCN antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- 1 mg/mL in 1X PBS, BSA free, sodium azide free
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储存液
- Azide free
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储存条件
- -20 °C
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储存方法
- Aliquot the recombinant DCN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Decorin (DCN)
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别名
- DCN
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背景
- Decorin is a small leucine-rich proteoglycan (SLRP) family member that consists of a glycosaminoglycan chain-containing core protein. The core protein contains ten leucine rich repeats that contain sites for glycosylation, flanked by disulfide bond stabilizing loops. Decorin binds to Collagen Type I, II and IV in vivo and promotes the formation of fibers with variations in stability and solubility. The Decorin core protein binds to growth factors, intercellular matrix molecules, such as Fibronectin and Thrombospondin, and to the Decorin endocytosis receptor. Decorin binds to and inhibits TGFbeta and is a direct or indirect negative modulator of TGFbeta synthesis. Inhibition of Decorin core protein gene expression by the combination of IFN-gamma and TNFAlpha may contribute to cartilage destruction that is characteristic of inflammatory joint diseases. For immunostaining, pre-incubation with chondroitinase-SBC or testicular hyaluronidase may be required to expose the epitope.
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UniProt
- P07585
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途径
- Glycosaminoglycan Metabolic Process
抗原
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