XAF1 抗体 (AA 197-301)
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北京 101111
Quick Overview for XAF1 抗体 (AA 197-301) (ABIN7871745)
抗原
See all XAF1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 197-301
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原理
- XIAP associated factor 1 Antibody / XAF1
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids Q197-S301) was used as the immunogen for the XIAP associated factor 1 antibody.
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亚型
- IgG
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anti-XiAP Associated Factor 1 (XAF1) (AA 151-250) antibody
XAF1 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 1-301) antibodyXAF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 235-269), (C-Term) antibodyXAF1 适用: 人 WB, IF 宿主: 兔 Polyclonal RB49525 unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 1-301) antibodyXAF1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (C-Term) antibodyXAF1 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 172-259) antibodyXAF1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 202-301) antibodyXAF1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E5 unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 201-218) antibodyXAF1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 107-156) antibodyXAF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 215-264) antibodyXAF1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the XIAP associated factor 1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the XIAP associated factor 1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- XAF1 (XiAP Associated Factor 1 (XAF1))
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别名
- XIAP associated factor 1
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背景
- XAF1, also called XIAP-associated factor 1, antagonizes the anti-caspase activity of XIAP and may be important in mediating apoptosis resistance in cancer cells. By genomic sequence analysis, the XAF1 gene contains 7 exons spanning 18 kb. Southern blot analysis suggested that XAF1 is a single-copy gene. The XAF1 gene is mapped on 17p13.1. Fluorescence microscopy demonstrated nuclear expression of XAF1, in contrast to the cytoplasmic expression of XIAP. Functional analysis indicated that XAF1 reverses the XIAP-mediated inhibition of CASP3 and its protection against apoptosis. Northern blot analysis detected wide expression of 3.9-, 4.5-, 6.0-, and 7.0-kb XAF1 transcripts, with highest levels in heart and ovary and lowest levels in brain and testis. Antisense experiments determined that loss of XAF1 expression enhances resistance to apoptosis. Alteration in XAF1 and XIAP RNA expression levels may lead to increased apoptotic resistance and proliferation due to unregulated XIAP function in cancer cells.
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UniProt
- Q6GPH4
抗原
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