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- 抗原 See all XAF1 抗体
- XAF1 (XiAP Associated Factor 1 (XAF1))
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抗原表位
- AA 235-269, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This XAF1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This XAF1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 235-269 amino acids from the C-terminal region of human XAF1.
- 克隆位点
- RB49525
- 亚型
- Ig Fraction
- Top Product
- Discover our top product XAF1 Primary Antibody
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anti-XiAP Associated Factor 1 (XAF1) (AA 151-250) antibody
XAF1 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 1-301) antibodyXAF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (C-Term) antibodyXAF1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 172-259) antibodyXAF1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 1-301) antibodyXAF1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 201-218) antibodyXAF1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 215-264) antibodyXAF1 适用: 人, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 202-301) antibodyXAF1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E5 unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 201-218) antibodyXAF1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-XiAP Associated Factor 1 (XAF1) (AA 107-156) antibodyXAF1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- IF: 1:25. WB: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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- 抗原
- XAF1 (XiAP Associated Factor 1 (XAF1))
- 别名
- XAF1 (XAF1 产品)
- 别名
- BIRC4BP antibody, HSXIAPAF1 antibody, XIAPAF1 antibody, Fbxo39 antibody, XIAP associated factor 1 antibody, xaf1 antibody, XAF1 antibody, Xaf1 antibody
- 背景
- Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti- caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha- induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin, the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.
- 分子量
- 34626
- UniProt
- Q6GPH4
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