Periostin 抗体 (AA 193-326)
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北京 101111
Quick Overview for Periostin 抗体 (AA 193-326) (ABIN7871690)
抗原
See all Periostin (POSTN) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 193-326
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原理
- Periostin Antibody / POSTN
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纯化方法
- Protein A/G affinity
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免疫原
- A recombinant partial protein sequence (within amino acids 193-326) from the human protein was used as the immunogen for the Periostin antibody.
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亚型
- IgG2b, kappa
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应用备注
- Optimal dilution of the Periostin antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Periostin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- Periostin (POSTN)
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别名
- Periostin
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背景
- Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for AlphaVBeta3 and AlphaVBeta5 integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor Beta 1 (TGF Beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.
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UniProt
- Q15063
抗原
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