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Periostin 抗体 (AA 193-326)

The 小鼠 单克隆 anti-Periostin antibody is suitable to detect Periostin in samples from 人. It has been validated for IHC (p).
产品编号 ABIN7871682
发货至: 中国
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Quick Overview for Periostin 抗体 (AA 193-326) (ABIN7871682)

抗原

See all Periostin (POSTN) 抗体
Periostin (POSTN)

适用

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宿主

  • 117
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小鼠

克隆类型

  • 99
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单克隆

标记

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This Periostin antibody is un-conjugated

应用范围

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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

POSTN-4096
  • 抗原表位

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    AA 193-326

    原理

    Periostin Antibody / POSTN

    纯化方法

    Protein G affinity

    免疫原

    A portion of amino acids 193-326 from human POSTN protein was used as the immunogen for the Periostin antibody.

    亚型

    IgG2b, kappa
  • 应用备注

    Optimal dilution of the Periostin antibody should be determined by the researcher.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the Periostin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    Periostin (POSTN)

    别名

    Periostin

    背景

    Periostin (PN), also designated osteoblast-specific factor 2 (OSF-2), is a disulfide linked protein originally isolated as a osteoblast-specific factor. Periostin is a secreted protein that binds heparin and functions as a ligand for AlphaVbeta3 and AlphaVbeta5 integrins. In preosteoblasts, Periostin acts as a cell adhesion molecule and plays a role in osteoblast recruitment, spreading and attachment. Periostin is mainly detected in lower gastrointestinal tract, aorta, stomach, placenta, uterus and breast tissues but is up-regulated in epithelial ovarian tumors and overexpressed in breast cancer. Expression of Periostin is increased by bone morphogenetic protein (BMP2) and transforming growth factor beta 1 (TGF beta 1). Periostin contains a typical signal sequence, followed by a cysteine-rich domain, a fourfold repeated domain, which shows homology with the insect protein fasciclin, and a C-terminal domain.

    UniProt

    Q15063
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