ERCC1 抗体 (AA 191-281)
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Quick Overview for ERCC1 抗体 (AA 191-281) (ABIN7871655)
抗原
See all ERCC1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 191-281
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原理
- ERCC1 Antibody
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纯化方法
- Protein A/G affinity
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免疫原
- A portion of amino acids 191-281 was used as the immunogen for the ERCC1 antibody.
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亚型
- IgG2b, kappa
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应用备注
- Optimal dilution of the ERCC1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the ERCC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- ERCC1 (Excision Repair Cross Complementing Polypeptide-1 (ERCC1))
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别名
- ERCC1
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背景
- Recognizes a protein of 110 kDa, identified as Excision Repair Cross Complementing 1 (ERCC1). It is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae, which is required in mitotic intrachromosomal recombination and repair. ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV)-induced DNA damage. High expression of ERCC1 has been linked to tumor progression in a variety of cancers including non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head, ovarian cancer and esophageal cancer.
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UniProt
- P07992
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途径
- DNA Damage Repair, Production of Molecular Mediator of Immune Response
抗原
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