DKC1 抗体 (AA 19-447)
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北京 101111
Quick Overview for DKC1 抗体 (AA 19-447) (ABIN7871593)
抗原
See all DKC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 19-447
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原理
- DKC1 Antibody / Dyskerin
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human DKC1 recombinant protein (Position: R19-R447) was used as the immunogen for the DKC1 antibody.
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亚型
- IgG
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anti-Dyskeratosis Congenita 1, Dyskerin (DKC1) antibody
DKC1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Dyskeratosis Congenita 1, Dyskerin (DKC1) (AA 1-514) antibodyDKC1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Dyskeratosis Congenita 1, Dyskerin (DKC1) (AA 1-180) antibodyDKC1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Dyskeratosis Congenita 1, Dyskerin (DKC1) antibodyKD Validated DKC1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 25GB3495 unconjugated Recombinant Antibody
anti-Dyskeratosis Congenita 1, Dyskerin (DKC1) (AA 1-514) antibodyDKC1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E10 unconjugated
anti-Dyskeratosis Congenita 1, Dyskerin (DKC1) antibodyDKC1 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB1810 unconjugated Recombinant Antibody
anti-Dyskeratosis Congenita 1, Dyskerin (DKC1) (AA 185-213) antibodyDKC1 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB26907 unconjugated
anti-Dyskeratosis Congenita 1, Dyskerin (DKC1) (AA 94-170) antibodyDKC1 适用: 人 WB, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Dyskeratosis Congenita 1, Dyskerin (DKC1) (AA 298-465) antibodyDKC1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Dyskeratosis Congenita 1, Dyskerin (DKC1) (AA 298-509) antibodyDKC1 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the DKC1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the DKC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- DKC1 (Dyskeratosis Congenita 1, Dyskerin (DKC1))
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别名
- DKC1
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背景
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DKC1 antibody detects Dyskerin, a nucleolar pseudouridine synthase essential for ribosomal RNA modification, telomerase stability, and small nucleolar RNP biogenesis. The UniProt recommended name is Dyskerin (DKC1). This enzyme catalyzes the isomerization of uridine to pseudouridine in rRNA and snRNA, ensuring ribosome maturation and translation fidelity.
Functionally, DKC1 antibody identifies a 514-amino-acid protein localized in the nucleolus and Cajal bodies. DKC1 associates with NOP10, NHP2, and GAR1 to form the H/ACA ribonucleoprotein complex that modifies rRNA and snRNA. It also binds the telomerase RNA component (TERC), stabilizing the telomerase complex for telomere elongation.
The DKC1 gene is located on chromosome Xq28 and is ubiquitously expressed in dividing and metabolically active cells. Dyskerin function is vital for maintaining ribosome synthesis, RNA quality control, and telomere homeostasis. Its activity directly influences cell growth and chromosomal stability.
Pathologically, mutations in DKC1 cause X-linked dyskeratosis congenita, a rare disorder characterized by bone marrow failure, premature aging, and cancer predisposition. Reduced DKC1 function leads to defective rRNA modification, impaired telomerase activity, and genomic instability. Research using DKC1 antibody supports studies in RNA processing, telomere biology, and genetic diseases.
DKC1 antibody is validated for western blotting, immunofluorescence, and immunohistochemistry to detect pseudouridine synthases and nucleolar proteins. NSJ Bioreagents provides DKC1 antibody reagents optimized for studies in ribosome biogenesis, telomerase function, and RNA modification.
Structurally, Dyskerin features a TruB-like catalytic domain with conserved aspartate essential for pseudouridylation activity, and a nuclear localization signal directing nucleolar import. This antibody aids in elucidating DKC1's role in ribonucleoprotein assembly and RNA modification fidelity. -
UniProt
- O60832
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途径
- Telomere Maintenance
抗原
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