STAMBP 抗体 (AA 187-424)
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北京 101111
Quick Overview for STAMBP 抗体 (AA 187-424) (ABIN7871512)
抗原
See all STAMBP 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 187-424
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原理
- STAMBP Antibody / STAM-binding protein
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human STAMBP recombinant protein (Position: K187-R424) was used as the immunogen for the STAMBP antibody.
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亚型
- IgG
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anti-STAM Binding Protein (STAMBP) (AA 100-270) antibody
STAMBP 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-STAM Binding Protein (STAMBP) (AA 1-424) antibodySTAMBP 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-STAM Binding Protein (STAMBP) (AA 355-383), (C-Term) antibodySTAMBP 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB32017 unconjugated
anti-STAM Binding Protein (STAMBP) (AA 1-424) antibodySTAMBP 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 1A8 unconjugated
anti-STAM Binding Protein (STAMBP) (AA 1-424) antibodySTAMBP 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-STAM Binding Protein (STAMBP) (AA 362-391), (C-Term) antibodySTAMBP 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-STAM Binding Protein (STAMBP) antibodySTAMBP 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-STAM Binding Protein (STAMBP) (N-Term) antibodySTAMBP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-STAM Binding Protein (STAMBP) (C-Term) antibodySTAMBP 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-STAM Binding Protein (STAMBP) (C-Term) antibodySTAMBP 适用: 人, 小鼠, Cow, 兔, Pig, 犬, 豚鼠, 马, 猴, Bat, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the STAMBP antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the STAMBP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- STAMBP (STAM Binding Protein (STAMBP))
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别名
- STAMBP
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背景
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STAMBP antibody detects STAM-binding protein, a deubiquitinating enzyme that regulates endosomal sorting, cytokine receptor trafficking, and signal termination. Encoded by the STAMBP gene on chromosome 2p13.1, this enzyme is a member of the JAMM (JAB1/MPN/Mov34 metalloenzyme) family of zinc-dependent deubiquitinases that cleave ubiquitin chains from endosomal cargo proteins. STAMBP plays a critical role in maintaining receptor turnover and preventing abnormal accumulation of ubiquitinated proteins within endosomes.
Structurally, STAMBP is a 424-amino-acid cytoplasmic protein of approximately 49 kilodaltons containing a JAMM motif responsible for zinc ion coordination and catalytic activity, as well as SH3-binding regions that enable interaction with signal transducing adaptor molecules (STAM1 and STAM2). It localizes to early endosomes and participates in the endosomal sorting complex required for transport (ESCRT) machinery, modulating trafficking of growth factor receptors such as EGFR and cytokine receptors after ligand binding.
The STAMBP antibody is widely used in cell signaling, membrane trafficking, and neurodevelopmental research to study ubiquitin processing, receptor regulation, and lysosomal degradation pathways. Western blot analysis detects a 49 kilodalton band corresponding to STAMBP, while immunofluorescence reveals punctate endosomal staining. This antibody enables precise detection of endosomal deubiquitinating enzyme activity and ESCRT complex assembly.
Functionally, STAMBP removes Lys63-linked ubiquitin chains from endosomal cargo proteins, facilitating recycling or degradation decisions within the endolysosomal pathway. Its activity prevents overactivation of growth factor signaling and supports normal receptor turnover. Mutations in STAMBP cause microcephaly-capillary malformation syndrome (MIC-CAP), a rare congenital disorder characterized by neurodevelopmental delay, seizures, and vascular malformations resulting from defective ubiquitin recycling. Altered STAMBP expression also contributes to tumor progression and immune dysregulation through prolonged receptor signaling. The STAMBP antibody provides a powerful tool for characterizing ubiquitin-dependent trafficking, growth factor regulation, and endosomal sorting mechanisms. NSJ Bioreagents validates this antibody for its applications, ensuring robust and reproducible detection in trafficking and signaling studies. -
UniProt
- O95630
抗原
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