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ACE2 抗体 (AA 18-805)

Name: ACE2 抗体 (AA 18-805)
SKU: ABIN7871435
Availability: OutOfStock

This 兔多克隆 antibody specifically detects ACE2 in WB, ELISA 和 FACS. It exhibits reactivity toward 人.

产品编号 ABIN7871435

发货至: 中国

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Quick Overview for ACE2 抗体 (AA 18-805) (ABIN7871435)

抗原

See all ACE2 抗体

ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

适用

人

宿主

兔

克隆类型

多克隆

标记

This ACE2 antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Discover our top product ACE2 Primary Antibody

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AA 18-805

原理

ACE2 Antibody / Angiotensin-converting enzyme 2

纯化方法

Immunogen affinity purified

免疫原

E.coli-derived human ACE2 recombinant protein (Position: Q18-F805) was used as the immunogen for the ACE2 antibody.

亚型

IgG
anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 601-700) antibody
ACE2 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 18-250) antibody
ACE2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) antibody
ACE2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal AC18F unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 93-464) antibody
ACE2 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 392-739) antibody
ACE2 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (N-Term) antibody
Verified ACE2 适用: 人 WB, IHC, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 773-805), (C-Term) antibody
ACE2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4819 unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 140-172) antibody
ACE2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 59-90) antibody
ACE2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Angiotensin I Converting Enzyme 2 (ACE2) (AA 351-450) antibody
ACE2 适用: 人, 小鼠 WB, ELISA, ICC, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal dilution of the ACE2 antibody should be determined by the researcher.

限制

仅限研究用
状态

Lyophilized

溶解方式

Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

储存条件

4 °C,-20 °C

储存方法

After reconstitution, the ACE2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
抗原

ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

别名

ACE2

背景

The ACE2 antibody targets Angiotensin-converting enzyme 2, a type I membrane glycoprotein encoded by the ACE2 gene. Angiotensin-converting enzyme 2 functions as a carboxypeptidase that cleaves angiotensin II to angiotensin (1-7), a peptide with vasodilatory and anti-inflammatory effects. By opposing the classical renin-angiotensin system, Angiotensin-converting enzyme 2 maintains cardiovascular, renal, and pulmonary homeostasis. The ACE2 antibody provides a critical reagent for studying blood-pressure regulation, viral entry mechanisms, and tissue-specific expression of this pivotal enzyme.

Angiotensin-converting enzyme 2 is expressed in the vascular endothelium, lungs, heart, kidneys, and intestinal epithelium. Its catalytic domain hydrolyzes angiotensin II to produce angiotensin (1-7), which signals through the Mas receptor to counteract vasoconstriction and fibrosis. The ACE2 antibody enables precise detection of this enzyme in tissues, helping define its role in vascular tone and inflammatory control. Loss or downregulation of ACE2 disrupts this protective axis, predisposing tissues to hypertension, oxidative stress, and organ injury.

In addition to its enzymatic role, Angiotensin-converting enzyme 2 serves as a functional receptor for several coronaviruses, including SARS-CoV and SARS-CoV-2. Viral spike proteins bind to the extracellular domain of ACE2 to mediate cell entry. The ACE2 antibody supports virology and pathogenesis studies by enabling analysis of receptor abundance and distribution across tissues. Mapping ACE2 expression helps clarify host susceptibility and disease severity patterns in respiratory and cardiovascular systems.

Beyond infection biology, ACE2 participates in glucose metabolism, heart remodeling, and kidney filtration. Experimental models show that enhancing ACE2 activity mitigates cardiac hypertrophy and diabetic nephropathy. The ACE2 antibody supports quantification of these protective effects and is frequently used to monitor therapeutic modulation of the renin-angiotensin system. Dysregulated ACE2 expression has also been linked to inflammatory lung injury and endothelial dysfunction.

The ACE2 antibody is validated for western blotting, immunohistochemistry, and immunofluorescence, producing clear membrane and cytoplasmic staining consistent with its localization. NSJ Bioreagents provides this antibody with verified specificity and reproducibility for cardiovascular, infectious-disease, and molecular-biology research. By enabling accurate detection of Angiotensin-converting enzyme 2, the ACE2 antibody supports exploration of vascular signaling, viral pathogenesis, and therapeutic strategies aimed at restoring physiological balance.

UniProt

Q9BYF1

途径

ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour