LSP1 抗体 (AA 174-278)
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Quick Overview for LSP1 抗体 (AA 174-278) (ABIN7871287)
抗原
See all LSP1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 174-278
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原理
- LSP1 Antibody / Lymphocyte Specific Protein 1
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纯化方法
- Protein G affinity chromatography
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免疫原
- A recombinant human partial protein (amino acids 174-278) was used as the immunogen for this LSP1 antibody.
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亚型
- IgG1, kappa
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应用备注
- Optimal dilution of the LSP1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the LSP1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- LSP1 (Lymphocyte-Specific Protein 1 (LSP1))
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别名
- LSP1
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背景
- LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.
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UniProt
- P33241
抗原
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