SETBP1 抗体 (AA 172-1519)
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Quick Overview for SETBP1 抗体 (AA 172-1519) (ABIN7871262)
抗原
See all SETBP1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 172-1519
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原理
- SETBP1 Antibody / SET binding protein 1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human SETBP1 recombinant protein (Position: S172-A1519) was used as the immunogen for the SETBP1 antibody.
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亚型
- IgG
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anti-SET Binding Protein 1 (SETBP1) (AA 1-242) antibody
SETBP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-SET Binding Protein 1 (SETBP1) (AA 1-242) antibodySETBP1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-SET Binding Protein 1 (SETBP1) (AA 501-600) antibodySETBP1 适用: 小鼠 ELISA, IF (cc), IF (p), IHC (fro), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SET Binding Protein 1 (SETBP1) (C-Term) antibodySETBP1 适用: 人, 小鼠, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the SETBP1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SETBP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SETBP1 (SET Binding Protein 1 (SETBP1))
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别名
- SETBP1
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背景
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SETBP1 antibody detects SET binding protein 1, a nuclear protein that interacts with the SET oncoprotein to regulate chromatin structure, gene expression, and cellular proliferation. SETBP1 modulates transcriptional programs controlling stem cell maintenance and oncogenic transformation. The SETBP1 antibody is used in studies of leukemia, developmental syndromes, and transcriptional regulation.
SETBP1 is encoded by the SETBP1 gene on human chromosome 18q12.3. The protein is approximately 170 kilodaltons and contains multiple AT-hook motifs for DNA binding, nuclear localization signals, and a SET-binding domain that mediates interaction with the SET protein, a known inhibitor of protein phosphatase 2A (PP2A). Through this interaction, SETBP1 indirectly modulates PP2A activity, influencing cell cycle progression and epigenetic control.
The SETBP1 antibody detects a 145-150 kilodalton band by western blot and shows nuclear localization under immunofluorescence. SETBP1 acts as a transcriptional regulator that binds GC-rich promoter regions to enhance expression of target genes, including HOXA cluster members associated with hematopoietic differentiation and leukemogenesis. Mutations that stabilize SETBP1 lead to aberrant accumulation, transcriptional reprogramming, and malignant transformation in myelodysplastic syndromes and acute myeloid leukemia.
In addition to cancer, germline mutations in SETBP1 cause Schinzel-Giedion syndrome, a severe developmental disorder characterized by craniofacial abnormalities and neurological impairment. These mutations increase SETBP1 stability, disrupt normal transcriptional repression, and impair neuronal differentiation. SETBP1 also interacts with chromatin-modifying complexes to coordinate histone acetylation and methylation status.
As a molecular bridge between SET and chromatin, SETBP1 integrates signaling pathways that regulate proliferation, apoptosis, and gene expression. NSJ Bioreagents provides a validated SETBP1 antibody optimized for western blot, immunocytochemistry, and chromatin studies, facilitating research into oncogenic transcriptional regulation and epigenetic mechanisms in disease. -
UniProt
- Q9Y6X0
抗原
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