CDC45 抗体 (AA 166-431)
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Quick Overview for CDC45 抗体 (AA 166-431) (ABIN7871157)
抗原
See all CDC45 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 166-431
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原理
- PORC-PI-1 Antibody / CDC45
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纯化方法
- Affinity purified
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免疫原
- A human recombinant partial protein (amino acids E166-A431) was used as the immunogen for the PORC-PI-1 antibody.
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亚型
- IgG1
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应用备注
- Optimal dilution of the PORC-PI-1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PORC-PI-1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- CDC45 (Cell Division Cycle 45 Homolog (S. Cerevisiae) (CDC45))
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别名
- PORC-PI-1
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背景
- CDC45 is a protein that in humans is encoded by the CDC45 gene. The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants.
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UniProt
- O75419
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途径
- Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
抗原
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