ATG16L1 抗体 (AA 161-190)
Our Local Distributor
北京 101111
Quick Overview for ATG16L1 抗体 (AA 161-190) (ABIN7871107)
抗原
See all ATG16L1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 161-190
-
原理
- ATG16L Antibody
-
纯化方法
- Antigen affinity purified
-
免疫原
- A portion of amino acids 161-190 from the human protein were used as the immunogen for the ATG16L1 Antibody.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- The stated application concentrations are suggested starting points. Titration of the ATG16L1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the ATG16L1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
-
-
- ATG16L1 (ATG16 Autophagy Related 16-Like 1 (ATG16L1))
-
别名
- ATG16L
-
背景
- Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The APG12-APG5-APG16L complex is esential for the elongation of autophagic isolation membranes. This complex initially associates in uniform distribution with small vesicle membranes. During membrane elongation, the complex partitions, with a great concentration building on the outer side of the isolation membrane. Upon completion of the formation of the autophagosome, the APG12-APG5-APG16L dissociates from the membrane.
-
UniProt
- Q676U5
-
途径
- Autophagy
抗原
-