Dnmt2 抗体 (AA 16-391)
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Quick Overview for Dnmt2 抗体 (AA 16-391) (ABIN7871074)
抗原
See all Dnmt2 (TRDMT1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 16-391
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原理
- Dnmt2 Antibody / DNA methyltransferase 2 / TRDMT1
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived mouse DNMT2/TRDMT1 recombinant protein (Position: M16-E391) was used as the immunogen for the Dnmt2 antibody.
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亚型
- IgG
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anti-tRNA Aspartic Acid Methyltransferase 1 (TRDMT1) (AA 1-391) antibody
TRDMT1 适用: 人 ELISA, WB, IF 宿主: 小鼠 Monoclonal 1E12 unconjugated
anti-tRNA Aspartic Acid Methyltransferase 1 (TRDMT1) (AA 1-391) antibodyTRDMT1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-tRNA Aspartic Acid Methyltransferase 1 (TRDMT1) (AA 346-375) antibodyTRDMT1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB1850 unconjugated
anti-tRNA Aspartic Acid Methyltransferase 1 (TRDMT1) (AA 170-269) antibodyTRDMT1 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-tRNA Aspartic Acid Methyltransferase 1 (TRDMT1) (AA 201-230), (N-Term) antibodyTRDMT1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2389 unconjugated
anti-tRNA Aspartic Acid Methyltransferase 1 (TRDMT1) (AA 201-230) antibodyTRDMT1 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-tRNA Aspartic Acid Methyltransferase 1 (TRDMT1) (AA 346-375) antibodyTRDMT1 适用: 人, 小鼠 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-tRNA Aspartic Acid Methyltransferase 1 (TRDMT1) antibodyTRDMT1 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-tRNA Aspartic Acid Methyltransferase 1 (TRDMT1) (AA 39-53) antibodyTRDMT1 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-tRNA Aspartic Acid Methyltransferase 1 (TRDMT1) (AA 1-391) antibodyTRDMT1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- Optimal dilution of the Dnmt2 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Dnmt2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- Dnmt2 (TRDMT1) (tRNA Aspartic Acid Methyltransferase 1 (TRDMT1))
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别名
- Dnmt2
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背景
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DNMT2 antibody detects DNA methyltransferase homolog 2, encoded by the TRDMT1 gene on chromosome 10p15.1. DNMT2 antibody is applied in research on epigenetics, RNA modification, and gene regulation. Although named DNA methyltransferase 2, DNMT2 primarily functions as an RNA methyltransferase that catalyzes cytosine-5 methylation at tRNA-Asp and other tRNAs, influencing translation fidelity and stability. Expression is detected in many tissues, including liver, brain, and hematopoietic cells, and is conserved across eukaryotes, reflecting its evolutionary importance.
Structurally, DNMT2 resembles other DNA methyltransferases, with a catalytic domain containing conserved motifs for S-adenosylmethionine (SAM) binding and cytosine methylation. However, it lacks extended regulatory domains found in DNMT1 and DNMT3, resulting in unique substrate specificity. The protein is ~39 kDa and localized predominantly in the nucleus but also found in cytoplasmic compartments associated with tRNA modification.
Functionally, DNMT2 catalyzes methylation of cytosine residues in tRNA, enhancing their stability and protecting against stress-induced cleavage. By modifying tRNAs, DNMT2 indirectly regulates protein synthesis and cellular stress responses. It has roles in development, hematopoiesis, and innate immunity. Knockout models reveal its importance in protecting against viral infections and maintaining genome stability under stress. Researchers use DNMT2 antibody to investigate RNA modifications, epigenetics, and translational control.
Clinically, DNMT2 has been linked to cancer, neurological disease, and viral infection. Altered expression contributes to tumorigenesis, with context-dependent roles as either tumor suppressor or oncogene. DNMT2 polymorphisms are studied for associations with neurodegenerative disorders and metabolic syndromes. Its antiviral roles suggest relevance for infection biology, as methylated tRNAs resist viral endonuclease degradation. NSJ Bioreagents supplies DNMT2 antibody to support research in epigenetics, RNA biology, and disease mechanisms.
Experimentally, DNMT2 antibody is used in western blotting to detect the ~39 kDa protein, in immunofluorescence to study nuclear and cytoplasmic localization, and in immunohistochemistry to analyze tissue-specific expression. RNA immunoprecipitation with DNMT2 antibody helps identify methylated RNA targets. -
UniProt
- O55055
抗原
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