USP15 抗体 (AA 151-180)
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北京 101111
Quick Overview for USP15 抗体 (AA 151-180) (ABIN7870973)
抗原
See all USP15 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 151-180
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原理
- USP15 Antibody
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 151-180 from the human protein was used as the immunogen for the USP15 antibody.
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亚型
- Ig Fraction
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应用备注
- The stated application concentrations are suggested starting points. Titration of the USP15 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the USP15 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- USP15 (Ubiquitin Specific Peptidase 15 (USP15))
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别名
- USP15
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背景
- Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
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UniProt
- Q9Y4E8
抗原
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