PHGDH 抗体 (AA 15-533)
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北京 101111
Quick Overview for PHGDH 抗体 (AA 15-533) (ABIN7870796)
抗原
See all PHGDH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 15-533
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原理
- PHGDH Antibody / D-3-phosphoglycerate dehydrogenase
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human PHGDH recombinant protein (Position: L15-F533) was used as the immunogen for the PHGDH antibody.
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亚型
- IgG
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anti-phosphoglycerate Dehydrogenase (PHGDH) (AA 1-533) antibody
PHGDH 适用: 人 WB, ELISA, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 4A3-1D6 unconjugated
anti-phosphoglycerate Dehydrogenase (PHGDH) antibodyKD Validated PHGDH 适用: 人 WB, FACS, IF (p) 宿主: 小鼠 Monoclonal 24GB14070 unconjugated
anti-phosphoglycerate Dehydrogenase (PHGDH) (N-Term) antibodyKO Validated PHGDH 适用: 人 WB, IF, IHC (p), IP, IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-phosphoglycerate Dehydrogenase (PHGDH) (AA 264-533) antibodyPHGDH 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-phosphoglycerate Dehydrogenase (PHGDH) (AA 140-168) antibodyPHGDH 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-phosphoglycerate Dehydrogenase (PHGDH) (AA 2-251) antibodyPHGDH 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-phosphoglycerate Dehydrogenase (PHGDH) (AA 140-168), (N-Term) antibodyPHGDH 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20882 unconjugated
anti-phosphoglycerate Dehydrogenase (PHGDH) (AA 249-277) antibodyPHGDH 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20883 unconjugated
anti-phosphoglycerate Dehydrogenase (PHGDH) (AA 249-277) antibodyPHGDH 适用: 人 WB, ELISA, IHC, FACS 宿主: 兔 Polyclonal unconjugated
anti-phosphoglycerate Dehydrogenase (PHGDH) (AA 1-533) antibodyPHGDH 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal dilution of the PHGDH antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the PHGDH antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- PHGDH (phosphoglycerate Dehydrogenase (PHGDH))
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别名
- PHGDH
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背景
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PHGDH antibody detects D-3-phosphoglycerate dehydrogenase, encoded by the PHGDH gene. D-3-phosphoglycerate dehydrogenase is a key enzyme in the serine biosynthesis pathway, catalyzing the conversion of 3-phosphoglycerate to 3-phosphohydroxypyruvate. PHGDH antibody provides researchers with a critical reagent for studying amino acid metabolism, cancer metabolism, and neurological disease.
D-3-phosphoglycerate dehydrogenase is the first and rate-limiting enzyme of the phosphorylated pathway of serine biosynthesis. Research using PHGDH antibody has shown that it links glycolysis to serine and glycine production, supporting nucleotide, lipid, and redox metabolism. This central role in metabolic reprogramming makes PHGDH particularly important in rapidly dividing cells and cancer biology.
Studies with PHGDH antibody have revealed that amplification and overexpression occur in multiple cancers, including melanoma, breast cancer, and glioma. Increased PHGDH expression enhances serine synthesis, fueling biosynthetic pathways that support tumor growth. Targeting PHGDH has therefore emerged as a potential therapeutic approach in oncology.
Beyond cancer, research using PHGDH antibody has highlighted roles in neurodevelopment and inherited metabolic disorders. Mutations in PHGDH cause serine deficiency disorders, leading to microcephaly, psychomotor retardation, and seizures. These findings demonstrate the dual clinical relevance of PHGDH in both metabolic disease and cancer.
Dysregulation of D-3-phosphoglycerate dehydrogenase has also been linked to immune function, as serine metabolism influences lymphocyte proliferation and differentiation. Research using PHGDH antibody continues to uncover links between metabolism, immune responses, and disease progression.
PHGDH antibody is widely used in western blotting, immunohistochemistry, and enzymatic activity assays. Western blotting quantifies enzyme expression in tumors and metabolic tissues, immunohistochemistry highlights localization in brain and cancer sections, and activity assays confirm catalytic function. These applications make PHGDH antibody indispensable for metabolic and cancer research.
By supplying validated PHGDH antibody reagents, NSJ Bioreagents supports studies into serine metabolism, cancer biology, and neurological disease. Detection of D-3-phosphoglycerate dehydrogenase provides researchers with insight into how amino acid metabolism supports physiology and pathology. -
UniProt
- O43175
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途径
- Metabolism of Steroid Hormones and Vitamin D, Warburg Effect
抗原
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