TCF4 抗体 (AA 147-176)
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Quick Overview for TCF4 抗体 (AA 147-176) (ABIN7870740)
抗原
See all TCF4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 147-176
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原理
- TCF4 Antibody / Transcription factor 4
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids Q147-V176) was used as the immunogen for the TCF4 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the TCF4 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the TCF4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- TCF4 (Transcription Factor 4 (TCF4))
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别名
- TCF4
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背景
- Transcription factor 4 (TCF-4) also known as immunoglobulin transcription factor 2 (ITF-2) is a protein that in humans is encoded by the TCF4 gene located on chromosome 18q21.2. This gene encodes transcription factor 4, a basic helix-loop-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is broadly expressed, and may play an important role in nervous system development. Defects in this gene are a cause of Pitt-Hopkins syndrome. In addition, an intronic CTG repeat normally numbering 10-37 repeat units can expand to >50 repeat units and cause Fuchs endothelial corneal dystrophy. Multiple alternatively spliced transcript variants that encode different proteins have been described.
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UniProt
- P15884
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途径
- WNT signaling, Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, Regulation of Hormone Metabolic Process, Carbohydrate Homeostasis, Stem Cell Maintenance, Protein targeting to Nucleus
抗原
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