HAS2 抗体 (AA 138-166)
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Quick Overview for HAS2 抗体 (AA 138-166) (ABIN7870582)
抗原
See all HAS2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 138-166
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原理
- Hyaluronan synthase 2 Antibody / HAS2
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 138-166 from the human protein was used as the immunogen for the Hyaluronan synthase 2 antibody.
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亚型
- IgG
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anti-Hyaluronan Synthase 2 (HAS2) (AA 67-170) antibody
HAS2 适用: 人 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 4E7 unconjugated
anti-Hyaluronan Synthase 2 (HAS2) (AA 138-166) antibodyHAS2 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22492 unconjugated
anti-Hyaluronan Synthase 2 (HAS2) antibodyHAS2 适用: 人, 小鼠, 大鼠 WB, IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronan Synthase 2 (HAS2) (AA 70-359) antibodyHAS2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Hyaluronan Synthase 2 (HAS2) antibodyHAS2 适用: 人 WB, ELISA, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal 4E7 unconjugated
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应用备注
- The stated application concentrations are suggested starting points. Titration of the Hyaluronan synthase 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Hyaluronan synthase 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
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- HAS2 (Hyaluronan Synthase 2 (HAS2))
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别名
- Hyaluronan synthase 2
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背景
- Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
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UniProt
- Q92819
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途径
- Glycosaminoglycan Metabolic Process
抗原
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