CASP5 抗体 (AA 137-434)
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Quick Overview for CASP5 抗体 (AA 137-434) (ABIN7870577)
抗原
See all CASP5 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 137-434
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原理
- Caspase-5 Antibody / CASP5
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纯化方法
- Antigen affinity purified
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免疫原
- Recombinant human protein (amino acids D137-N434) was used as the immunogen for the Caspase-5 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the Caspase-5 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the Caspase-5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- CASP5 (Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))
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别名
- Caspase-5
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背景
- This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein, this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
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UniProt
- P51878
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途径
- Inflammasome
抗原
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