RNF111 抗体 (AA 134-994)
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Quick Overview for RNF111 抗体 (AA 134-994) (ABIN7870535)
抗原
See all RNF111 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 134-994
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原理
- RNF111 Antibody / RING finger protein 111
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纯化方法
- Immunogen affinity purified
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免疫原
- E.coli-derived human RNF111 recombinant protein (Position: F134-S994) was used as the immunogen for the RNF111 antibody.
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亚型
- IgG
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anti-Ring Finger Protein 111 (RNF111) (AA 1-108) antibody
RNF111 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 1C4 unconjugated
anti-Ring Finger Protein 111 (RNF111) (AA 1-985) antibodyRNF111 适用: 人 WB, IHC (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 111 (RNF111) antibodyRNF111 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 111 (RNF111) (AA 1-985) antibodyRNF111 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 111 (RNF111) (C-Term) antibodyRNF111 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 111 (RNF111) (AA 209-237), (N-Term) antibodyRNF111 适用: 人 WB 宿主: 兔 Polyclonal RB38613 unconjugated
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应用备注
- Optimal dilution of the RNF111 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the RNF111 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- RNF111 (Ring Finger Protein 111 (RNF111))
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别名
- RNF111
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背景
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RNF111 antibody detects RING finger protein 111, an E3 ubiquitin-protein ligase that regulates DNA damage signaling, TGF-beta signaling, and transcriptional control. Also known as Arkadia, RNF111 facilitates ubiquitin-dependent degradation of transcriptional repressors to enhance signal transduction. The RNF111 antibody is used in studies of ubiquitin signaling, DNA repair, and cancer biology.
RNF111 is encoded by the RNF111 gene on human chromosome 15q22.33. The protein is approximately 101 kilodaltons and contains a RING finger domain, two nuclear localization signals, and several coiled-coil regions. It acts as an E3 ligase that mediates ubiquitination of SMAD7 and SKI, thereby amplifying TGF-beta and BMP signaling cascades that control differentiation and tissue remodeling.
The RNF111 antibody identifies a 100-105 kilodalton nuclear protein by western blot. Immunofluorescence reveals punctate nuclear distribution consistent with its role in transcriptional regulation. RNF111 participates in DNA damage response through ubiquitination of SUMO-modified proteins at sites of double-strand breaks, promoting recruitment of repair factors. Loss or mutation of RNF111 results in defective DNA repair and impaired transcriptional activation of TGF-beta-responsive genes.
RNF111 also modulates embryonic development, neural differentiation, and tumor suppression. Overexpression has been associated with hepatocellular carcinoma, whereas downregulation disrupts differentiation signaling in stem cells. NSJ Bioreagents provides a validated RNF111 antibody, supporting investigation of ubiquitin signaling, DNA repair pathways, and transcriptional regulation. -
UniProt
- Q6ZNA4
抗原
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