SART1 抗体 (AA 125-800)
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Quick Overview for SART1 抗体 (AA 125-800) (ABIN7870382)
抗原
See all SART1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 125-800
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原理
- SART1 Antibody
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纯化方法
- Antigen affinity purified
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免疫原
- E. coli-derived recombinant human protein (amino acids K125-K800) was used as the immunogen for the SART1 antibody.
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亚型
- IgG
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应用备注
- Optimal dilution of the SART1 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the SART1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- SART1 (Squamous Cell Carcinoma Antigen Recognized By T Cells (SART1))
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别名
- SART1
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背景
- U4/U6.U5 tri-snRNP-associated protein 1 is a protein that in humans is encoded by the SART1 gene. This gene encodes two proteins, the SART1(800) protein expressed in the nucleus of the majority of proliferating cells, and the SART1(259) protein expressed in the cytosol of epithelial cancers. The SART1(259) protein is translated by the mechanism of -1 frameshifting during posttranscriptional regulation, its full-length sequence is not published yet. The two encoded proteins are thought to be involved in the regulation of proliferation. Both proteins have tumor-rejection antigens. The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer patients. This SART1(259) antigen may be useful in specific immunotherapy for cancer patients and may serve as a paradigmatic tool for the diagnosis and treatment of patients with atopy. The SART1(259) protein is found to be essential for the recruitment of the tri-snRNP to the pre-spliceosome in the spliceosome assembly pathway.
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UniProt
- O43290
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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