RNF20 抗体 (AA 123-389)
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Quick Overview for RNF20 抗体 (AA 123-389) (ABIN7870352)
抗原
See all RNF20 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 123-389
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原理
- RNF20 Antibody / BRE1A
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纯化方法
- Antigen affinity purified
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免疫原
- E. coli-derived recombinant human protein (amino acids E123-S389) was used as the immunogen for the RNF20 antibody.
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亚型
- IgG2b
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应用备注
- Optimal dilution of the RNF20 antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- After reconstitution, the RNF20 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- RNF20 (Ring Finger Protein 20 (RNF20))
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别名
- RNF20
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背景
- E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene. The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS).
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UniProt
- Q5VTR2
抗原
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